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Cannabinoids

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Cannabinoids are naturally occurring chemical compounds found in the cannabis plant that interact with the body’s endocannabinoid system (ECS)—a network of receptors involved in regulating many physiological functions like mood, pain, appetite, sleep, and immune response.

 

There are three main types of cannabinoids:

 

1. Phytocannabinoids (from cannabis)

These are the cannabinoids found in cannabis plants. Some of the most well-known include:

 

  • THC (tetrahydrocannabinol) – The primary psychoactive compound responsible for the “high.”

  • CBD (cannabidiol) – Non-psychoactive; known for potential benefits like reducing anxiety, inflammation, and seizures.

  • CBG (cannabigerol) – A precursor to other cannabinoids; studied for mood, pain, and antibacterial properties.

  • CBC (cannabichromene) – Non-intoxicating; may support pain relief and neurogenesis.

  • CBN (cannabinol) – Formed as THC degrades; mildly psychoactive with potential sedative effects.

 

2. Endocannabinoids (from the body)

These are produced naturally by the human body and include:

 

  • Anandamide – Sometimes called the “bliss molecule”; binds to cannabinoid receptors and helps regulate mood and appetite.

  • 2-AG (2-arachidonoylglycerol) – Involved in regulating immune function and inflammation.

 

3. Synthetic Cannabinoids

Man-made compounds designed to mimic natural cannabinoids. Some are used medically (e.g., dronabinol) while others (e.g., Spice, K2) are illegal and often dangerous.

 

What Do Cannabinoids Do?

Cannabinoids bind to CB1 and CB2 receptors in the body:

 

  • CB1 receptors are mainly in the brain and central nervous system—linked to mood, memory, and pain perception.

  • CB2 receptors are found in the immune system—linked to inflammation and pain relief.

 

Together with terpenes, cannabinoids contribute to the entourage effect, where compounds work together to enhance each other’s therapeutic potential.

 

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“TAC” – Total Active Cannabinoids

TAC, or Total Active Cannabinoids, refers to the combined percentage of all active cannabinoids in a cannabis product, including THC. It’s more than just THC; it encompasses other cannabinoids like CBD, CBN, and CBG, providing a broader picture of the product’s overall potency and potential effects.

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CBCV (Cannabichromevarin)

CBCV (Cannabichromevarin) is a minor cannabinoid found in cannabis, structurally related to CBC (Cannabichromene), but with a slight variation in its chemical structure. Like other varin-type cannabinoids, CBCV has a propyl side chain rather than the more common pentyl side chain found in CBC and other cannabinoids like THC and CBD.

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CBDV (Cannabidivarin)

CBDV (Cannabidivarin) is a non-psychoactive cannabinoid found in cannabis and hemp, closely related to CBD (Cannabidiol) in structure and effects. It’s a member of the “varin” family of cannabinoids, which are known for having a shorter side chain than their more common counterparts.

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CBL (Cannabicyclol)

CBL (Cannabicyclol) is a lesser-known, non-psychoactive cannabinoid found in the cannabis plant. It’s considered a degradation product, meaning it forms when other cannabinoids—mainly CBC (Cannabichromene)—break down over time due to light, heat, or air exposure.

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CBNA (Cannabinolic Acid)

CBNA (Cannabinolic Acid) is the acidic precursor to CBN (Cannabinol) and is found in raw, unheated cannabis. It forms when THCA (tetrahydrocannabinolic acid) is exposed to oxygen over time, undergoing a natural process called oxidation.

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CBDA (Cannabidiolic acid)

Cannabidiolic acid, is a cannabinoid produced in cannabis plants. It is the precursor to cannabidiol. It is most abundant in the glandular trichomes on the female seedless flowers or more accurately infructescence often colloquially referred to as buds or flowers.

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CBC (Cannabichromene)

Cannabichromene (CBC) is a non-psychoactive cannabinoid found in cannabis, meaning it doesn’t produce a “high” like THC. It’s considered one of the “big six” cannabinoids and is being studied for its potential therapeutic effects, including anti-inflammatory, anti-nociceptive, and anti-cancer properties.

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THCV (Tetrahydrocannabivarin)

THCV (Tetrahydrocannabivarin) is a psychoactive cannabinoid found in cannabis, known for its distinct effects compared to Delta-9 THC. It shares a similar chemical structure with THC but tends to produce different effects on the body and mind.

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CBCA (Cannabichromenenic acid)

CBCA (Cannabichromenic Acid) is the acidic precursor to CBC (Cannabichromene), one of the lesser-known, non-psychoactive cannabinoids found in cannabis. Like other cannabinoid acids, CBCA exists in raw, unheated cannabis and decays into CBC when exposed to heat (through decarboxylation).

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CBN (Cannabinol)

CBN (Cannabinol) is a mildly psychoactive cannabinoid found in cannabis, best known as a byproduct of THC degradation. When THC ages—due to exposure to heat, light, or oxygen—it breaks down into CBN. That’s why older cannabis often has higher levels of CBN.

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CBDVA (Cannabidivarinic acid)

Cannabidivarinic acid (CBDVA) is the carboxylic acid precursor of cannabidivarin (CBDV), a close chemical relative to cannabidiol (CBD). All of these substances originate in Cannabis sativa, and CBDVA, CBDV, and CBD share more similarities than differences.

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CBLA (Cannabicyclolic Acid)

CBLA (Cannabicyclolic Acid) is the acidic precursor to CBL (Cannabicyclol) — a rare and non-psychoactive cannabinoid. Like many other cannabinoid acids, CBLA exists naturally in raw, unheated cannabis, and it degrades from CBCA (Cannabichromenic Acid) over time, especially when exposed to light or heat.

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*Cannabis is for use only by adults 21 years of age or older. All information contained herein is for educational purposes only. None of this information should be interpreted as medical or treatment advice for any person or condition. Always consult with a licensed physician in all matters regarding your health. View our Disclaimer.